UMBRELLA PLUS - molecular-driven treatments for kidney cancer
Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.
Designing a safer way to find and fight acute myeloid leukaemia cells in children
Investigating a protein found on leukaemia stem cells, the cells which cause relapse, and whether it could be a good drug target.
Understanding how lymphatic vessels talk to childhood kidney cancers
Investigating a new theory for how kidney cancer grows and spreads.
Could ‘prehabilitation’ help prepare children with cancer for a stem cell transplant?
Investigating whether diet or lifestyle changes could help children cope with bone marrow transplants better.
Could a medicine called ONC-201 help treat children with T-cell acute lymphoblastic leukaemia?
Looking at whether a pre-existing drug could be an effective and safe treatment due to its ability to target cancer cells directly.
What are the origins of liver cancer in children and why does treatment sometimes fail?
Understanding how hepatocellular carcinoma develops and what role the immune system plays.
Detecting lingering brain cancer cells before a tumour grows back
Ependymoma comes back after treatment around half of the time, because some cancer cells are still alive. If doctors could identify these cells and diagnose relapsed ependymoma sooner, children could start treatment earlier.
What role do small pieces of genetic code play in germ cell tumours?
Investigating how different levels short non-coding RNAs affect germ cell tumour cells, and testing whether medicines altering these levels could be a potential treatment.
Studying the origins of childhood acute myeloid leukaemia to identify targets for kinder and more effective treatments
Learning more about leukaemia cells in order to design targeted treatments that can increase survivorship and quality of life.