Exploring how osteosarcoma cells spread and survive elsewhere in the body
Dr Olivier Pardo at Imperial College London aims to find out how osteosarcoma cells survive the bloodstream and spread elsewhere in the body.
Optimising drug treatment for childhood cancer patients
It is particularly difficult to treat some groups of childhood cancer patients, especially infants in their first weeks of life. This application is to fund this rapidly developing research programme for two years, involving the treatment of 150-200.
Investigating a new way of treating poor-prognosis rhabdomyosarcoma
Evaluating a novel protein methyltransferase inhibitor for poor-prognosis rhabdomyosarcoma therapy
Delivering packaged drugs into paediatric brain tumours using ultrasound
Diffuse midline glioma is a devastating brain tumour, affecting primarily young children. There’s currently no cure for this disease and treatment options are limited. This is mainly because this type of tumour is well-protected from drugs by the ‘blood-brain barrier’. This barrier physically blocks all medications from entering the brain. Our group has developed new methods of bypassing this barrier using focused ultrasound.
Fighting circular DNA to prevent relapse in acute lymphoblastic leukaemia
Looking at whether medicines that prevent circular DNA replication can help prevent relapse.
Understanding how neuroblastoma and immune cells join forces
Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.
Understanding how childhood cancers spread
Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.
Understanding how a new drug can selectively fight childhood cancer cells
Testing a new type of targeted treatment that applies to multiple types of childhood cancers.
Making an ‘off-the-shelf’ CAR-T cell treatment for children with solid cancers
Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.