Discovering the differences between craniopharyngiomas that regrow after treatment and those that don't

Craniopharyngiomas are a type of brain tumour that grows slowly, destroying important parts of the brain and resulting in significant harm to patients. Current treatments are radiotherapy and surgery, however despite these, a proportion of patients' tumours regorw, often recurrently, causing further damage. This project seeks to identify the underlying biological differences between tumours that regrow and those that don't. The aim is to reveal 'markers' that may help predict those tumours at most risk of regrowth and identify new molecular targets for therapies. In addition, the project will look at the effect of radiotherapy on the tumour tissue.