Understanding how childhood cancers spread
Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.
How do immune cells protect childhood ependymoma tumours?
Looking at how brain tumours hijack immune cells, forcing them to support cancer growth instead of fighting it.
Rewriting cancer cell messages to slow down tumour growth
Testing medicines that can correct the genetic messages that help cancer cells grow out of control.
Investigating the shape of fusion genes in rhabdomyosarcoma
How the 3D shape of fusion gene genetic code affects cancer cell behaviour and whether shape-modifying medicines could mitigate these effects.
Understanding how lymphatic vessels talk to childhood kidney cancers
Investigating a new theory for how kidney cancer grows and spreads.
Designing a safer way to find and fight acute myeloid leukaemia cells in children
Investigating a protein found on leukaemia stem cells, the cells which cause relapse, and whether it could be a good drug target.
Developing ways to identify chemotherapy resistant B-cell acute lymphoblastic leukaemia cells
Developing a test that can measure the amount of chemotherapy-resistant leukaemia cells in patient's blood samples. This would provide the foundations for future research.
Understanding CaMK1D in diffuse large B cell lymphoma in children
Understanding how a protein affects the growth and development of lymphoma cells in order to build the foundations for safer and more effective treatments.
Studying the origins of childhood acute myeloid leukaemia to identify targets for kinder and more effective treatments
Learning more about leukaemia cells in order to design targeted treatments that can increase survivorship and quality of life.