Discovering new blood-based signals for monitoring brain tumours in children
Dr Alina Pandele at the University of Nottingham hopes to find fragments cancer cell genetic code in the blood which can help doctors know when ependymoma grows back.
Looking for early signs on brain MRIs that can predict whether young people with ependymoma will go on to experience cognitive problems
Professor Shivaram Avula will identify markers in the brains of young people with brain tumours that will help predict the development of long-term side effects like learning and memory problems.
A new approach to deliver chemotherapy directly into brain tumours
Professor Rylie Green at Imperial College London will test a device that can deliver chemotherapy directly to brain tumours, sparing healthy cells.
Fighting brain cancer with CAR-T cells: Targeting zombie cells to improve therapy
Dr Ashley Vardon at the University of Birmingham hopes to find a way to effectively fight diffuse midline glioma with new immunotherapies.
Evaluating a new antibody-based targeted treatment for medulloblastoma
Dr Laura Donovan is testing a targeted treatment for medulloblastoma in the hopes of giving incurable patients new treatment options.
Using tiny particles in blood and cerebrospinal fluid to improve the diagnosis and treatment of childhood brain tumours
Dr Timothy Ritzmann aims to improve ependymoma care and treatment by harnessing the potential of extracellular vesicles.
Delivering packaged drugs into paediatric brain tumours using ultrasound
Diffuse midline glioma is a devastating brain tumour, affecting primarily young children. There’s currently no cure for this disease and treatment options are limited. This is mainly because this type of tumour is well-protected from drugs by the ‘blood-brain barrier’. This barrier physically blocks all medications from entering the brain. Our group has developed new methods of bypassing this barrier using focused ultrasound.
How do immune cells protect childhood ependymoma tumours?
Looking at how brain tumours hijack immune cells, forcing them to support cancer growth instead of fighting it.
What are the effects of radiation and chemotherapy on children’s developing brains?
Looking at the differences between healthy brain cells before and after treatment to uncover the mechanisms behind brain-related late effects.