UMBRELLA PLUS - molecular-driven treatments for kidney cancer
Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.
We have been funding expert research since 2016, aiming to ensure that every child and young person has a safe and effective treatment for their cancer, and that they can live long and happy lives post-treatment.
Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.
Investigating a protein found on leukaemia stem cells, the cells which cause relapse, and whether it could be a good drug target.
Learning more about leukaemia cells in order to design targeted treatments that can increase survivorship and quality of life.
Developing a test that can measure the amount of chemotherapy-resistant leukaemia cells in patient's blood samples. This would provide the foundations for future research.
Looking at whether a pre-existing drug could be an effective and safe treatment due to its ability to target cancer cells directly.
Ependymoma comes back after treatment around half of the time, because some cancer cells are still alive. If doctors could identify these cells and diagnose relapsed ependymoma sooner, children could start treatment earlier.
Investigating how different levels short non-coding RNAs affect germ cell tumour cells, and testing whether medicines altering these levels could be a potential treatment.
Understanding how hepatocellular carcinoma develops and what role the immune system plays.
Assessing the advantages and disadvantages of gastronomies and nasogastric tubes to help children who lose weight on cancer treatment.