Fighting circular DNA to prevent relapse in acute lymphoblastic leukaemia
Looking at whether medicines that prevent circular DNA replication can help prevent relapse.
Making an ‘off-the-shelf’ CAR-T cell treatment for children with solid cancers
Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.
Understanding how a new drug can selectively fight childhood cancer cells
Testing a new type of targeted treatment that applies to multiple types of childhood cancers.
Rewriting cancer cell messages to slow down tumour growth
Testing medicines that can correct the genetic messages that help cancer cells grow out of control.
Determining the best approach to treat children with relapsed anaplastic large cell lymphoma
Looking at why ALCL sometimes relapses with a new targeted treatment, and understanding how to optimise this treatment approach.
Making Wilms tumour cells go green
Developing a new dye to make kidney cancer surgery safer and more effective.
UMBRELLA PLUS - molecular-driven treatments for kidney cancer
Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.
Could ‘prehabilitation’ help prepare children with cancer for a stem cell transplant?
Investigating whether diet or lifestyle changes could help children cope with bone marrow transplants better.
Could a medicine called ONC-201 help treat children with T-cell acute lymphoblastic leukaemia?
Looking at whether a pre-existing drug could be an effective and safe treatment due to its ability to target cancer cells directly.