Identifying new treatment options for Burkitt lymphoma that doesn’t respond to treatment
Using Burkitt lymphoma models to find essential survival genes to target for therapy.
MonoGerm clinical trial – is one chemotherapy medicine safer for germinomas?
Testing whether treatment could be safely reduced for children with germinoma brain tumours
Understanding chemotherapy doesn’t work as well for some children with neuroblastoma
Investigating how cancer cells can keep dividing and why this makes it harder to treat.
Creating a new combination treatment for children's brain tumours
Repurposing medicines to support a new type of immunotherapy for brain tumours.
Using anti-depressants to improve immunotherapy for neuroblastoma
Using anti-depressants to prevent the body's immune system from fighting immunotherapy treatments.
How do DNA cutting errors lead to relapsed childhood leukaemia
Looking at how a process called 'cut-and-run' leads to genetic errors, and how those errors could be prevented in order to prevent relapse in childhood leukaemia.
Creating a new immunotherapy approach to fight aggressive medulloblastoma
Finding a way to use immunotherapy against a high-risk type of childhood brain tumour.
Repurposing alcohol-abuse medicines to treat brain tumours
Understanding how a repurposed drug attacks and kills diffuse midline glioma cells.
Blocking processes which keep leukaemia cells alive
Investigating the possibility of combining a medicine that blocks the process with a medicine that triggers a cell's defensive response to treat ALL.