Harnessing the immune system to treat Ewing sarcoma in the lungs
Dr Jonathan Fisher aims to create an 'off the shelf' version of immunotherapy to for hard-to-treat Ewing sarcoma.
Investigating the role of a PRMT5 in Ewing sarcoma and its potential as a target for treatment
Professor Clare Davies and Dr Susanne Gatz explore whether PRMT5 inhibitors could be an effective and kinder treatment for Ewing sarcoma.
Stopping the alpha - a potential new treatment approach for osteosarcoma
Professor Plevin and Dr Margaret Cunningham will investigate an enzyme that might play a role in osteosarcoma development, and see whether this could form the basis of a new type of treatment.
Understanding existing research about ambulatory chemotherapy for children and young people
Dr Jess Morgan at the University of York hopes to understand what we already know about using portable chemotherapy pumps for children with cancer.
Optimising drug treatment for childhood cancer patients
It is particularly difficult to treat some groups of childhood cancer patients, especially infants in their first weeks of life. This application is to fund this rapidly developing research programme for two years, involving the treatment of 150-200.
Understanding how neuroblastoma and immune cells join forces
Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.
Fighting circular DNA to prevent relapse in acute lymphoblastic leukaemia
Looking at whether medicines that prevent circular DNA replication can help prevent relapse.
Making an ‘off-the-shelf’ CAR-T cell treatment for children with solid cancers
Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.
Understanding how a new drug can selectively fight childhood cancer cells
Testing a new type of targeted treatment that applies to multiple types of childhood cancers.