Finding the most beneficial dose of fludarabine to optimise CAR-T therapy
Dr Shelby Barnett and Dr Geoff Shenton will monitor crucial drug levels in patients' blood in order to improve CAR T therapy protocols.
Tracking individual osteosarcoma cells to understand how they dodge chemotherapy
Dr Lucia Cottone at University College London hopes to understand how osteosarcoma cells become resistant to chemotherapy, which has a big impact on patient survival.
Optimising drug treatment for childhood cancer patients
It is particularly difficult to treat some groups of childhood cancer patients, especially infants in their first weeks of life. This application is to fund this rapidly developing research programme for two years, involving the treatment of 150-200.
Understanding how childhood cancers spread
Looking at how cancer cells alter the scaffolding inside the body that organises cells in order to spread and make new tumours.
Making an ‘off-the-shelf’ CAR-T cell treatment for children with solid cancers
Creating an immunotherapy that can be delivered to patients more quickly and cost-effectively.
Fighting circular DNA to prevent relapse in acute lymphoblastic leukaemia
Looking at whether medicines that prevent circular DNA replication can help prevent relapse.
Understanding how a new drug can selectively fight childhood cancer cells
Testing a new type of targeted treatment that applies to multiple types of childhood cancers.
Understanding how neuroblastoma and immune cells join forces
Studying how neuroblastoma cells and immune cells interact over time to see how the cancer adapts to treatment.
How do immune cells protect childhood ependymoma tumours?
Looking at how brain tumours hijack immune cells, forcing them to support cancer growth instead of fighting it.