Understanding how Wilms tumour stem cells escape chemotherapy
Investigating cancer stem cells in Wilms tumour to see whether they are responsible for relapse, and to understand how that happens.
Protecting young hearts from chemotherapy-related heart problems
Investigating whether giving a medicine before doxorubicin cancer treatment could prevent heart damage.
Targeting a relapse causing protein to treat childhood acute myeloid leukaemia
Investigating how a protein that causes relapse in acute myeloid leukaemia interacts with the genetic code, and whether these interactions could be prevented.
Investigating nanomedicines to make treatment safer for children with cancer
Looking at how nanoparticles could improve drug delivery and reduce toxicity for young cancer patients.
Developing a kinder and more effective immunotherapy for neuroblastoma
Modifying current immunotherapy so that it doesn't cause damage to nerve cells and instead targets three molecules to help kill neuroblastoma cells more effectively.
Understanding what the red flags are in aggressive neuroblastoma to improve and develop treatments
Finding out which changes to how DNA is read in neuroblastoma can give doctors more information about the cancer, and investigating whether these changes could be stopped through medicines.
Investigating an amino acid to improve medulloblastoma treatment
Looking at how medulloblastoma brain tumours use an amino acid, and whether blocking access to that resource would make cancer cells more susceptible to treatment.
Investigating why some children get leukaemia after treatment for other cancers
Looking at the early stages of leukaemia that develops after treatment for other cancers to find out what changes occur and how to fight it.
Assessing a potent drug combination to fight Wilms tumour
Using two drugs to prevent an essential Wilms tumour protein interacting with a growth-promoting protein, and testing this treatment in patient samples.