UMBRELLA PLUS - molecular-driven treatments for kidney cancer
Improving genetic testing for children with kidney cancers like Wilms tumour and finding a way to improve diagnosis and relapse monitoring.
Understanding how lymphatic vessels talk to childhood kidney cancers
Investigating a new theory for how kidney cancer grows and spreads.
Designing a safer way to find and fight acute myeloid leukaemia cells in children
Investigating a protein found on leukaemia stem cells, the cells which cause relapse, and whether it could be a good drug target.
Could a medicine called ONC-201 help treat children with T-cell acute lymphoblastic leukaemia?
Looking at whether a pre-existing drug could be an effective and safe treatment due to its ability to target cancer cells directly.
What are the origins of liver cancer in children and why does treatment sometimes fail?
Understanding how hepatocellular carcinoma develops and what role the immune system plays.
What role do small pieces of genetic code play in germ cell tumours?
Investigating how different levels short non-coding RNAs affect germ cell tumour cells, and testing whether medicines altering these levels could be a potential treatment.
A new immunotherapy treatment for paediatric high-grade glioma
Creating a new immunotherapy that will attacks collagen in cancer cells, and testing whether it is effective in model systems to make it the best it can be.
How does MYCN change the way genetic information is read?
Understanding how the MYCN protein changes the amounts of other proteins in the cell by changing the way DNA is processed and translated.
Understanding how Wilms tumour stem cells escape chemotherapy
Investigating cancer stem cells in Wilms tumour to see whether they are responsible for relapse, and to understand how that happens.