Our research projects

Assessing the advantages and disadvantages of gastronomies and nasogastric tubes to help children who lose weight on cancer treatment.

Ewing sarcoma is the second most common bone tumour in young people. The primary goal of this project is to fast-track a targeted drug combination for evaluation in clinical trials, with the aim of improving outcomes and minimising treatment associated morbidities for Ewing sarcoma patients.

Osteosarcoma bone cancer affects teenagers, around half of whom die within 5-years of diagnosis. We think we can solve these problems by modifying immune cells called “gamma-delta T-cells”.

Drug repurposing targeting immunomodulatory Haem oxygenase-1 (HO-1) for prevention of osteosarcoma growth and metastasis

Optimising tyrosine kinase inhibitor therapy in newly diagnosed metastatic Ewing sarcoma

Investigating repurposed drugs to decrease the progression of Ewing’s sarcoma

Repurposing of drugs targeting drug resistant self-renewing Ewing’s sarcoma cells to accelerate new treatments into clinical trials to improve outcomes.

Identifying molecular drivers of disease progression in Ewing’s sarcoma