Can we improve survival by changing frontline treatments for high-risk medulloblastoma?
Dr Rebecca Hill and her team hope to develop new tools to test chemotherapy options that will combine with radiotherapy to treat high-risk medulloblastoma.
Mapping connections with the brain in diffuse midline glioma
Professor Darren Hargrave aims to study electrical signals in the brain which could help diffuse midline glioma spread.
Investigating how ependymoma uses proteins to spread through cerebrospinal fluid
Dr Timothy Ritzmann will investigate how proteins that regulate water inside the body could help ependymoma grow and spread.
Finding a cure for aggressive acute myeloid leukaemia in children
Professor Owen Williams hopes to develop a combination treatment with a revolutionary new drug that can more effectively fight acute myeloid leukaemia.
Discovering more about the development of childhood germ cell tumours
Dr Harry Leitch at Great Ormond Street Institute of Child Health will grow early reproductive cells in the lab to understand how germ cell tumours form and help develop new ways to test treatments.
Fine-tuning a new CAR T cell and drug combination for testing in solid childhood cancers
Professor John Anderson will test a new type of CAR T cell therapy designed to help children with solid cancers.
Using a DNA molecule as a new and safer treatment for neuroblastoma
Professor Arturo Sala will test a promising new adult cancer treatment in neuroblastoma to find a kinder and more effective treatment options.
Helping immunotherapy work better for children with neuroblastoma by reprogramming the tumour environment
Professor James Arnold is creating a new type of immunotherapy that can fight solid tumours and make it easier for the immune system to help.
Evaluation and optimization of drug combinations that kill neuroblastoma cancer cells
Professor Karim Malik aims to test a new combination of drugs that can eliminate neuroblastoma cells.
Investigating a new type of drug that can inhibit the growth and survival of neuroblastoma and other childhood cancers
Professor Karim Malik and Dr Jodie Bojko are testing drugs that can prevent cancer cells from making growth-promoting proteins.
Creating advanced models to test new treatments for malignant rhabdoid tumours
Dr Daniel Williamson’s expert team will find the best malignant rhabdoid tumour models to test exciting new treatments.
Finding the best way to make two cancer-targeting T cells for the price of one
Professor John Anderson at University College London hopes to develop a cost-effective CAR T-cell combination therapy.