Lead investigator: Dr Suzanne Turner, University of Cambridge
Funded by CCLG
Funded July 2018
Award: £8047.00
Histones are the core packaging system of DNA in our cells, responsible for ensuring that the DNA code is protected and read at the correct times in a cell’s lifecycle. How histones do this is controlled by small changes to their structure as a result of modifications to the histone protein. These modifications can be aberrantly altered in cancer cells so that the reading of the DNA code is disrupted. We have found that two key histones are modified on previously unrecognised sites in a form of cancer called Anaplastic Large Cell Lymphoma (ALCL) which will be investigated further in this project.