Improving our understanding of how chemotherapy works in hepatoblastoma

Hepatoblastoma is a type of liver cancer that usually affects children younger than three years old. In order to develop new drugs to combat this devastating disease, it is vital that we continue to explore new avenues of scientific research. Recently it has been show that a modification to our DNA, which normally regulates the activity of our genes, called 5-hydroxymethylcytosine, is altered in several cancer types. This study will look at this change in hepatoblastoma tissue and in patients receiving chemotherapy treatment in order to understand how this cancer behaves, and how chemotherapy acts upon it.