Can we identify an 'ultra-high-risk' type of neuroblastoma?

High risk neuroblastoma accounts for 50% of neuroblastomas and is one of the most difficult childhood cancers to cure with a less than 50% 5 year survival rate. Currently, we cannot predict which patients will be cured. By studying gene expression using a technique called RNAseq we hope to identify an ultra-high risk group. However, as frozen tissue for RNAseq is limited we will use formalin fixed paraffin embedded material from 4 cases previously studied by RNAseq on frozen tissue. In addition, we will study 4 paired frozen tumours from diagnosis and relapse by RNAseq to study tumour evolution with time.