Targeting childhood brain tumours from within: using a smart gel to deliver immunotherapy
Dr Karolina Dziemidowicz and her team at University College London aim to help CAR-T cells get to and fight an aggressive brain cancer.
Using RNA to alter the metabolism in acute myeloid leukaemia cells
Dr Carmela De Santo at the University of Birmingham hopes to find a way to protect immune cells from acute myeloid leukaemia, so that they can fight the cancer.
PRECISION‑CSF: A new test to help personalise treatment for children with leukaemia
Professor Christina Halsey at the University of Glasgow hopes to improve testing of leukaemia cells around the brain, helping children receive the right amount of treatment.
Investigating an immunotherapy combination treatment for neuroblastoma
Professors Suzanne Turner, Anna Philpott and Aditi Vedi at the University of Cambridge will test a new combination treatment for neuroblastoma that could make current immunotherapies more effective.
Activating a protein to make immunotherapy more effective for neuroblastoma
Professor Aymen Al-Shamkhani at the University of Southampton hopes to test a way to recruit immune cells into neuroblastoma tumours, making immunotherapy more effective.
Investigating how ependymoma uses proteins to spread through cerebrospinal fluid
Dr Timothy Ritzmann will investigate how proteins that regulate water inside the body could help ependymoma grow and spread.
Fine-tuning a new CAR T cell and drug combination for testing in solid childhood cancers
Professor John Anderson will test a new type of CAR T cell therapy designed to help children with solid cancers.
Finding a cure for aggressive acute myeloid leukaemia in children
Professor Owen Williams hopes to develop a combination treatment with a revolutionary new drug that can more effectively fight acute myeloid leukaemia.
Discovering more about the development of childhood germ cell tumours
Dr Harry Leitch at Great Ormond Street Institute of Child Health will grow early reproductive cells in the lab to understand how germ cell tumours form and help develop new ways to test treatments.