Fine-tuning a new CAR T cell and drug combination for testing in solid childhood cancers
Professor John Anderson will test a new type of CAR T cell therapy designed to help children with solid cancers.
Finding a cure for aggressive acute myeloid leukaemia in children
Professor Owen Williams hopes to develop a combination treatment with a revolutionary new drug that can more effectively fight acute myeloid leukaemia.
Discovering more about the development of childhood germ cell tumours
Dr Harry Leitch at Great Ormond Street Institute of Child Health will grow early reproductive cells in the lab to understand how germ cell tumours form and help develop new ways to test treatments.
Evaluation and optimization of drug combinations that kill neuroblastoma cancer cells
Professor Karim Malik aims to test a new combination of drugs that can eliminate neuroblastoma cells.
Using a DNA molecule as a new and safer treatment for neuroblastoma
Professor Arturo Sala will test a promising new adult cancer treatment in neuroblastoma to find a kinder and more effective treatment options.
Helping immunotherapy work better for children with neuroblastoma by reprogramming the tumour environment
Professor James Arnold is creating a new type of immunotherapy that can fight solid tumours and make it easier for the immune system to help.
Discovering new blood-based signals for monitoring brain tumours in children
Dr Alina Pandele at the University of Nottingham hopes to find fragments cancer cell genetic code in the blood which can help doctors know when ependymoma grows back.
Developing new cancer treatment testing models for children with leukaemia
Dr Katrina Lappin aims to create a cost effective and more accurate acute myeloid leukaemia model to test treatments on.
Reading critical changes in neuroblastoma’s genetic messages
Dr Jodie Bojko at the University of Bristol hopes to understand how genetic instructions are altered in neuroblastoma, and how this impacts the cancer.