Understanding how childhood medulloblastoma begins to identify new treatments
Dr Sarah Badodi at Queen Mary University of London will use new models to discover how and why medulloblastoma develops, identifying new ways to target the cancer.
Using DNA damage to target osteosarcoma
Professor Sophie Postel-Vinay and Dr Lucia Cottone at University College London will look at whether osteosarcoma cells need a molecule called M1 to survive damage to their DNA.
Does radiotherapy make aggressive childhood brain tumours resistant to further treatment?
Dr Thomas Oliver at University College London will investigate whether the genetic changes caused by radiotherapy could make diffuse midline glioma tumours less responsive to other treatments.
Can we improve survival by changing frontline treatments for high-risk medulloblastoma?
Dr Rebecca Hill and her team hope to develop new tools to test chemotherapy options that will combine with radiotherapy to treat high-risk medulloblastoma.
Mapping connections with the brain in diffuse midline glioma
Professor Darren Hargrave aims to study electrical signals in the brain which could help diffuse midline glioma spread.
Finding kinder drugs in genetically matched cell models for childhood leukaemia
Professor Alex Thompson and his team at the University of Nottingham aim to learn more about leukaemia to support the development of kinder treatments.
Investigating the role of SET in childhood acute myeloid leukaemia to develop new treatments
Dr Maria Teresa Esposito hopes to learn more about a gene called SET in leukaemia and will test the best medicines to fight it.
Unravelling the behaviour of individual lymphoma cells to find out why the cancer can relapse or resist treatment
Professor Suzanne Turner will investigate the behaviour of individual lymphoma cells in order to find out why treatments fail.
Exploring how osteosarcoma cells spread and survive elsewhere in the body
Dr Olivier Pardo will investigate how osteosarcoma cells which escape into the bloodstream survive to spread elsewhere in the body.