Children’s Cancer and Leukaemia Group (CCLG) is proud to announce a new research project aiming to improve diagnosis and monitoring of Wilms tumour, a type of childhood kidney cancer.
Funded by CCLG Special Named Funds Bethany’s Wish, Daniel’s Rainbow Fund, Finlay’s Fund, Freddie’s Fight and The Georgie B Fund, the project will look for tiny molecules that can diagnose Wilms tumour and predict how a patient’s cancer will respond to treatment. The project, titled ‘Validating circulating biomarkers of Wilms tumour’, is led by Professor Matthew Murray, who is a researcher at the University of Cambridge and paediatric oncologist at Addenbrooke’s Hospital. His goal is to help doctors diagnose this cancer more quickly and accurately and know whether children are responding properly to treatment.
In order to develop a non-invasive test that can be used to diagnose and monitor children with Wilms tumour, Professor Murray’s team will look for tiny molecules, called biomarkers, in blood and urine samples from children with this disease. If the biomarkers are only present when there is a Wilms tumour, then doctors could test for their presence in blood or urine samples to diagnose children faster.
Prof Matthew Murray said:
At the moment, most children in Europe start chemotherapy treatment when doctors suspect that they have a Wilms tumour based on the typical clinical picture – including consideration of factors like the child’s age and scan findings. Whilst this assumption is correct in the majority of patients, this is only confirmed when the tumour is removed, which normally happens four to five weeks after starting chemotherapy.
We believe that the test we are developing, which requires less than half a teaspoon of blood, will one day help to confirm that the child has Wilms tumour at the time of initial presentation.
We anticipate that it will also allow careful monitoring of the tumour’s response to chemotherapy and identify patients early on who might need a different treatment approach. This would improve survival outcomes for young cancer patients.
Bethany’s Wish was set up as an independent charity in 2013 before becoming a CCLG Special Named fund in 2017. Its supporters have raised over £85,000 for Wilms tumour research in memory of seven-year-old Bethany Polanco, who passed away from the disease in 2012.
This study marks the fourth project Bethany’s Wish has helped to fund with CCLG, and Bethany’s mum, Angela, said she was “overwhelmed, humbled and inspired to hear that Bethany's legacy is still able to live on”.
She said:
In the beginning we had no idea how big and wide-reaching Bethany's Wish would be and we are thankful to each and every person that takes the time to donate and remember our girl.
Funding research was one of the main aims of Bethany's Wish - we wanted to support families but also look deeper into why Wilms tumours happen, how we can find them earlier and how we can treat those like Bethany that do not respond as expected.
Angela added: “To have been able to fund research into the tumour that took away my little girl is truly an honour.
“Every step we can make into finding more about the disease and how to stop any more children suffering is so important. Funding high-quality research is the only way to save more lives.”
The researchers will also be comparing the different biomarkers, alongside with the patients’ history, to see whether any of these can tell doctors new information about patients, such as the risk group of the Wilms tumour.
This project is the first step towards validating the test in larger numbers of patients in Wilms tumour clinical trials, to make sure that it is suitable for use as standard clinical practice.
Ashley Ball-Gamble, CEO of CCLG, said:
We’d like to express our deepest thanks to all the Special Named Funds who helped to fund this project.
CCLG’s goal is to fund research into all types of cancer as we believe that every child deserves a safe and effective treatment for their cancer, regardless of how rare it is. Our Special Named Fund programme and the passion and drive of our families is a vital to achieving this.
This project was funded by CCLG’s Special Named Funds, which enable families to raise money for research into specific types of childhood cancer, while honouring a child or young person affected by cancer by raising funds in their name.